GIT1 protects traumatically injured spinal cord by prompting microvascular endothelial cells to clear myelin debris.
Wan B, Li C, Wang M, Kong F, Ding Q, Zhang C, Liu H, Qian D, Deng W, Chen J, Tang P, Wang Q, Zhao S, Zhou Z, Xu T, Huang Y, Gu J, Fan J, Yin G.
Wan B, et al.
Aging (Albany NY). 2021 Feb 17;13(5):7067-7083. doi: 10.18632/aging.202560. Epub 2021 Feb 17.
Aging (Albany NY). 2021.
PMID: 33621952
Free PMC article.
In this study, we demonstrated that GIT1 may prompt MECs to clear myelin debris via autophagy and further stimulate MECs angiogenesis via upregulating VEGF. Our results indicate that GITI may serve as a promising target for accelerating myelin debris clearance and improvin …
In this study, we demonstrated that GIT1 may prompt MECs to clear myelin debris via autophagy and further stimulate MECs angiogenesis via up …